SMART High throughput facility @ S.L.R.I. , Toronto, Ontario, Canada

CHEMICAL LIBRARIES

The SLRI currently has:

Maybridge HTS Collection (50,000 diverse chemicals with drug-like properties);

Maybridge HitFinder™ Collection (16,000 chemicals);

DIVERSet™ Collection (Chembridge) (10,000 drug-like chemicals);

LOPAC (Sigma) (1280 chemicals with proven biological activity);

BIOMOL collection (361 biologically- and pharmacologically-active compounds);

Prestwick collection (Prestwick Chemical) (1120 compounds of which >85% are marketed drugs);

Spectrum collection (MicroSource) (2000 compounds made of off-patent drugs, experimental bioactives, and ~700 natural products with pharmacological activity);

Seminatural compounds (AnalytiCon Discovery) (4000 compounds made from 8 natural scaffolds [ie. (i) quinic acid and shikimic acid, (ii) acidhydroxy proline, (iii) santonine, (iv) dianhydro-D-Glucitol, (v) hydroxy pipecolinic acid, (vi) andrographolide, (vii) piperazine-2-carboxylic acid, and (viii) cytisine]. Each scaffold was decorated through medicinal chemistry rationales to generate 500 derivatives;

NIH Clinical Collection (BioFocusDPI) (450 compounds, of which most are drugs that have been tested in phase I-III clinical trials);

RNA TECHNOLOGY

siRNA libraries

Dharmacon Reversioned siRNA SMARTpool Library, Whole Human siGENOME (~18,150 gene targets)
Available in the following subset collections:
GPCR, Druggable targets, Ubiquitin Conjugation, Ion Channels, Proteases, Kinases, Phosphatases

Dharmacon siRNA SMARTpool Library, Whole Mouse siGENOME (~16,500 gene targets)
Available in the following subset collections:
Kinases, GPCR, Druggable targets

Dharmacon Reversioned Deconvolved siRNA Library, Whole Human siGENOME
composed of 4 siRNA unique sequences for each SMARTpool sample of the Whole Human Genome Library; ~72,600 samples

Dharmacon Deconvolved siRNA Library Whole Mouse siGENOME
composed of 4 siRNA unique sequences for each SMARTpool reagent in the Whole Mouse Genome Library; ~66,000 samples

Ambion Silencer™ Drosophila RNAi Library, 13071 samples

miRNA libraries

miRIDIAN® microRNA Mimics (HUMAN)
miRIDIAN® microRNA Hairpin Inhibitors (HUMAN)
Dharmacon, Version 10.1 - 810 samples based upon (based upon Sanger miRBase Sequence Database)

miRIDIAN® microRNA Mimics (MOUSE)
miRIDIAN® microRNA Hairpin Inhibitors (MOUSE)
Dharmacon, Version 10.1 - 642 samples based upon (based upon Sanger miRBase Sequence Database)

Service Information
Mandate

To provide academic communities with the widest array of high-throughput technologies and the opportunity to carry out research strategies leading to output comparable to that produced by the most advanced biotech and pharmaceutical companies.
Vision

To expand scope and objectives of academic science, foster collaborations in multidisciplinary contexts, bridge the gap between basic and applied research, identify new prospects in drug discovery research and forge new investment opportunities.
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